Welcome to the Shoichet Lab
"Our research program requires a cross disciplinary approach where aspects of engineering, chemistry, and biology are applied to the fields of Regenerative Medicine, Tissue Engineering and Drug Delivery. We approach unsolved problems in medicine by creating a series of design criteria which we then use to formulate solutions."
Ontario Chief Scientist Dr. @MollyShoichet & her team (@ShoichetLab @UofT) are engineering new materials to help restore vision to people who lose their sight from diseases like age-related #maculardegeneration. Just 1 of the amazing ways #WeAreOntarioInnovation pic.twitter.com/KXaLSe1f3t
— OntarioInnovation (@OntInnovation) April 19, 2018
The Numbers
Features
AmacaThera
AmacaThera to commence Phase 1 clinical trial for non-opiod, post-operative pain management. PR Newswire
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Margolese National Brain Disorders Prize
Congratulations to Professor Molly Shoichet on receiving the Margolese National Brain Disorders Prize. Chem Eng News, University of TorontoUniversity of British Columbia, Faculty of Medicine
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Feature of the Month
Please join me in congratulating Amber and Daniela on being awarded an NSERC PROMOTE. Amber was also awarded an OGS. We would also like to congratulate Muhammad Rizwan and Laura Smith on their paper that is published in Advanced Functional Materials.
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UofT Engineering Researchers Develop Cell Injection Technique that could Help Reverse Vision Loss
The Shoichet lab’s research to restore vision after degenerative blinding disease reached the airwaves on Eye On Vision, on FM89.3 WYPL in Memphis, TN. This highlights our research recently published in Biomaterials. University of Toronto Engineering News
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Recent Publications
Publication
“Photochemically-activated notch signaling hydrogel preferentially differentiates human derived hepatoblasts to cholangiocytes” Rizwan M; Fokina A; Kivijärvi T; Ogawa M; Kufleitner M; Laselva O; Smith LJ; Bear CE; Ogawa S; Keller G; Shoichet MS. 2020 , Advanced Functional Materials, 2006116; doi: 10.1002/adfm.202006116 Publication
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Publication
“Re-engineering Biocatalysts: Computational Redesign of Chondroitinase ABC Improves Efficacy and Stability” Hettiaratchi MH; O’Meara MJ; O’Meara TR; Pickering AJ; Letko-Khait N; Shoichet MS. 2020 , Science Advances, 6: eabc6378; doi: 10.1126/sciadv.abc6378 Publication
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“Hydrogel-mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration” Mitrousis, N.; Hacibekiroglu, S.; Ho, M.T.; Sauvé, Y.; Nagy, A.; van der Kooy, D.; Shoichet, M.S. 2020 Biomaterials, 257: 120233; doi: 10.1016/j.biomaterials.2020.120233 Publication
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Publication
“Attenuated diphtheria toxin mediates siRNA delivery” Arnold AE; Smith LJ; Beilhartz G; Bahlmann LC; Jameson E; Melnyk R; Shoichet MS. 2020 Science Advances, 6 : eaaz4848; doi: 10.1126/sciadv.aaz4848 Publication
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