Welcome to the Shoichet Lab
"Our research program requires a cross disciplinary approach where aspects of engineering, chemistry, and biology are applied to the fields of Regenerative Medicine, Tissue Engineering and Drug Delivery. We approach unsolved problems in medicine by creating a series of design criteria which we then use to formulate solutions."
The Numbers
FEATURES
Feature of the Month
Self-assembling cholangiocytes form bile duct-like structure similar to that in liver tissue – selected as frontispiece cover. Check out the full paper here. We would also like to congratulate Tim Cheung and Amber Xue in having their paper published in ACS Applied Materials and Interfaces.
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Fellow of the National Academy of Inventors
Professor Molly Shoichet has been elected as a 2022 Fellow of the National Academy of Inventors (NAI) for having demonstrated a highly prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on the welfare of society. University of Toronto Engineering News
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New Strategy for Delivery of Therapeutic Proteins could Help Treat Degenerative Eye Diseases
Finding treasures in the trash: with directed evolution, we find affibody binding partners that are highly specific with moderate affinity allowing simultaneous release of multiple factors. University of Toronto Engineering News
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U of T Researchers Design New Hydrogel for more Targeted Cancer Treatments
Biomimetic 3D hyaluronan hydrogel enables culture of multiple cancer cell types and unbiased in vivo results. University of Toronto News
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RECENT PUBLICATIONS
Publication
“Protein Release by Controlled Desorption from Transiently Cationic Nanoparticles” Cheung TH; Xue A; Kurtz DA; Shoichet M. 2023 , ACS Applied Materials and Interfaces (special issue), in press xx1-x14; doi: doi.org/10.1021/acsami.2c19877 Publication
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Publication
“Tunable surface charge enables the electrostatic adsorption-controlled release of neuroprotective peptides from a hydrogel-nanoparticle drug delivery system” Ho E; Deng Y; Akbar D; Da K; Létourneau M; Morshead CM; Chatenet D; Shoichet MS”, ACS Applied Materials & Interfaces, 15: 91-105 doi: 10.1021/acsami.2c17631 Publication
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Publication
“Affibody-mediated controlled release of fibroblast growth factor 2” Bostock C; Teal CJ; Dang M; Golinski AW; Hackel BJ; Shoichet MS. 2022 , J. Controlled Release, 350: 815-828; doi: 10.1016/j.jconrel.2022.09.004 Publication
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Publication
“Viscoelastic notch signaling hydrogel induces liver bile duct organoid growth and morphogenesis” Rizwan M; Ling C; Guo C; Liu T; Jiang JX; Bear CE; Ogawa S; Shoichet MS. 2022 , Advanced Healthcare Materials, 2200880: 1-14; doi: 10.1002/adhm.202200880 Publication
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