Welcome to the Shoichet Lab
"Our research program requires a cross disciplinary approach where aspects of engineering, chemistry, and biology are applied to the fields of Regenerative Medicine, Tissue Engineering and Drug Delivery. We approach unsolved problems in medicine by creating a series of design criteria which we then use to formulate solutions."
Ontario Chief Scientist Dr. @MollyShoichet & her team (@ShoichetLab @UofT) are engineering new materials to help restore vision to people who lose their sight from diseases like age-related #maculardegeneration. Just 1 of the amazing ways #WeAreOntarioInnovation pic.twitter.com/KXaLSe1f3t
— OntarioInnovation (@OntInnovation) April 19, 2018
The Numbers
Features
Feature of the Month: September – October 2019
Congratulations to Petro Czupiel. Dr. Czupiel successfully defended his PhD in May. He is joined by Dr. Shoichet at the Fall Convocation. We would also like to congratulate Dr. Ellie Arnold who successfully defended her PhD in October.
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Fellow, The Royal Society
On July 12, 2019, Dr. Molly Shoichet joined her colleagues Dr. Ben Blencowe and Dr. Barbara Sherwood-Lollar in being admitted as Fellows of the Royal Society. Chem-Eng NewsUofT News
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International Union of Pure and Applied Chemistry
On February 7, 2019, the International Union of Pure and Applied Chemistry (IUPAC) named Dr. Molly Shoichet a 2019 Distinguished Woman in Chemistry or Chemical Engineering. International Union of Pure and Applied Chemistry Chemical Engineering News Chemistry and Industry (April 2019)
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AmacaThera
AmacaThera, a Toronto-based company commercializing hydrogel-based drug delivery platforms, has raised $3.25 million CAD in seed financing from Sprout BioVentures, Viva Biotech, and Grey Sky Venture Partners. AmacaThera’s founding technology was discovered at the University of Toronto by Dr. Molly Shoichet, a leading expert on polymer design. AmacaThera envisions their proprietary…
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Recent Publications
Publication
“Benchmarking to the gold standard: hyaluronan-oxime hydrogels recapitulate xenograft models with in vitro breast cancer spheroid culture” Baker AEG; Bahlmann LC; Tam RY; Liu JC; Ganesh AN; Mitrousis N; Marcellus R; Spears M; Bartlett MS; Cescon DW; Bader GD; Shoichet MS. 2019 Advanced Materials, e1901166; doi: 10.1002/adma.201901166 Publication
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Publication
"Triggered Release Enhances the Cytotoxicity of Stable Colloidal Drug Aggregates" Donders E; Ganesh AN; Torosyan H; Lak P; Shoichet BK; Shoichet MS. 2019 ACS Chemical Biology, 14: 1507-14; doi: 10.1021/acschembio.9b00247 Publication
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Publication
“Cationic block amphiphiles show anti-mitochondrial activity in multi-drug resistant breast cancer cells” Czupiel, P.P.; Delplace, V.; Shoichet, M.S. 2019. J. Controlled Release, 305: 210-19; doi: 10.1016/j.jconrel.2019.04.045 Publication
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Publication
“Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains” Hettiaratchi MH; O’Meara MJ; Teal CJ; Payne SL; Pickering AJ; Shoichet MS. 2019 J.Controlled Release, 297: 14-25; doi: 10.1016/j.jconrel.2019.01.033 Publication
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