The main focus of my research at the Donnelly Centre is to develop treatment strategies to promote tissue repair after spinal cord injury. The complexity of the CNS and its response to injury dictates that the latest advances in bioengineering and macromolecular chemistry have to be implemented in the design of treatment strategies intended to promote CNS tissue repair. Therefore we intend to deliver stem-cell derived cells within hydrogels to the injured spinal cord.
Nov. 2011 - Sept. 2012
June 2006 - Oct. 2010
Oct. 2002 - May 2006
Short-Term Training Grant 2007, NeuroNRW
EU Travel Grant RegMedTeach
Deumens, S.F. Van Gorp, A. Bozkurt, C. Beckmann, T. Führmann, K. Montzka, R. Tolba, E. Kobayashi, I. Heschel, J. Weis, G.A. Brook. Motor outcome and allodynia are largely unaffected by novel olfactory ensheathing cell grafts to repair low-thoracic lesion gaps in the adult rat spinal cord. Behavioural Brain Research 2012,237:185-189.
T. Führmann, L. M. Hillen, K. Montzka, M. Wöltje, G. A. Brook. Cell-Cell Interactions of Human Neural Progenitor-Derived Astrocytes within a Microstructured 3D-Scaold. Biomaterials 2010, 31:7705-7715.
T. Führmann, K. Montzka, L.M. Hillen, D. Hodde, A. Dreier, A. Bozkurt, M. Wöltje, G.A. Brook. Axon growth-promoting properties of human bone marrow mesenchymal stromal cells. Neuroscience Letters 2010, 474:37-41.
T. Führmann, J. Gerardo-Nava, G. A. Brook (2010) Tissue Engineering: Central Nervous System. Chapter 12. pp 221-244. In Tissue Engineering. From Lab to Clinic. Eds Pallua N, Suschek C. Springer Verlag, London, Heidelberg, Dordrecht, New York. DOI: 10.1007/978-3-642-02824-3.
K. Montzka, T. Führmann, J. Müller-Ehmsen, M. Wöltje and G. A. Brook. Growth factor and cytokine expression of human mesenchymal stromal cells is not altered in an in vitro model of tissue damage. Cytotherapy 2010, Nov;12(7):870-80.
K. Montzka, T. Führmann, M. Wöltje, G.A. Brook. Expansion of human bone marrow-derived mesenchymal stromal cells: serum-reduced medium is better than conventional medium. Cytotherapy 2010, Sep;12(5):587-92.
J. Gerardo-Nava*, T. Führmann*, K. Klinkhammer, N. Seiler, J. Mey, D. Klee, M. Möller, P.D. Dalton, G.A. Brook. Human Neural and Glial Interactions with Electrospun Nanofibres in vitro. Nanomedicine 2009, Jan;4(1):11-30. *These authors contributed equally to this work and are first authors
K. Montzka*, N. Lassonczyk*, B. Tschöke, S. Neuss, T. Führmann, R. Franzen, R. Smeets, G.A. Brook, M. Wöltje. Neural differentiation potential of human bone marrow derived mesenchymal stromal cells: misleading marker gene expression. BMC Neuroscience 2009, 10:16. *These authors contributed equally to this work and are first authors
A. Bozkurt*, R. Deumens*, J Scheel, D.M. O'Dey, J. Weis, E.A. Joosten, T. Führmann, G.A. Brook, N. Pallua. CatWalk gait analysis in assessment of functional recovery after sciatic nerve injury. Journal of Neuroscience Methods 2008, 173:91-98. *These authors contributed equally to this work and are first authors
T. Führmann, M. Ghosh, T. Dargaville, D. D. Pearse and P. D. Dal-ton. Peptide functionalized nanoparticles for targeted drug delivery. Abstract and oral presentation, 9th World Biomaterial Congress, Chengdu, China.
T. Führmann, K. Montzka, R. Deumens, D. Hodde and G. Brook. 2012 Human neural progenitor-derived astrocyte-seeded collagen scaf-folds promote axon regeneration following spinal cord injury. Abstract and poster presentation, 9th World Biomaterial Congress, Chengdu, China.
T. Führmann, L. M. Hillen, K. Montzka, Dr. M. Wöltje and PD Dr. G. A. Brook. An In vitro study of the Effect of Human Foetal Neural Progenitor-derived Astrocytes on Axon Regeneration in 2D and 3D Culture Systems. Abstract and poster presentation, 7th International Stem Cell School in Regenerative Medicine, Prague, Czech Republic.
T. Führmann, R. Quertainmont, K. Montzka, R. Franzen and G. A. Brook. Implantation of human neural progenitor-derived astrocytes in an experimental model of spinal cord compression injury. Abstract and poster presentation, Neurovisionen 5, Bochum, Germany.
T. Führmann, K. Montzka, L. M . Hillen, G. A. Brook. An in vitro investigation of the effects of multipotent human progenitors and their astroglial derivates on DRG axonal growth. Abstract and poster presentation, 5th International Meeting of the Stem Cell Network NRW, Aachen, Germany.
T. Führmann, K. Montzka, L. M. Hillen and G.A. Brook. Multipotent stem/progenitor cells and their derivatives promote adult rat DRG neurite outgrowth. Abstract and poster presentation, BioStar, the 3rd International Congress on Regenerative Biology and Medicine and the 3rd Congress of the German Society for Stem Cell Research, Stuttgart, Germany.
T. Führmann, K. Montzka, L. M. Hillen and G.A. Brook. Investigation of adult rat DRG neurite outgrowth on multipotent stem/progenitor cells and their derivatives. Abstract and poster presentation, 25th Inter-national Summer School of Brain Research, Amsterdam, Netherlands.
T. Führmann, K. Montzka, M. Wöltje and G.A. Brook. Astrocytes Derived from Adult Neural Stem and Mesenchymal Stromal Cells for Spinal Cord Repair. Abstract and poster presentation, 6. ACRC Work-shop, Kerkrade, Netherlands.
T. Führmann, A. Roozbehi, D. Fischer, N. Zhelyaznik, K. Schra-ge and J. Mey. Expression of retinoic acid receptors RARalpha and RARbeta and retinoid X receptors after optic nerve injury. Abstract and poster presentation, 5th Forum of European Neuroscience, Vienna, Austria.
T. Führmann, A. Roozbehi, N. Zhelyaznik, K. Schrage, D. Fischer and J. Mey. Abstract and poster presentation, Expression of retinoic acid receptors RARa, RARb and retinoid X receptors after optic nerve injury. Abstract und poster presentation, 9th EURON Ph.D.-students days, Liege, Belgium.
Research Associate, 2018-present