Lymphangioleiomyomatosis (LAM) is a rare lung disease characterized by the destruction of lung tissue by LAM cells. These cells are difficult to isolate and culture by traditional 2D cell culture methods, which presents a major obstacle in the study of LAM. My project deals with the development of a faithful cell culture model for LAM using biomimetic hyaluronan based hydrogels as a medium for 3D cell culture.
BSc Honours Bio-organic Chemistry, Minor in Interdisciplinary Life Sciences
First Class Honours, Distinction
Thesis Supervisor: Dr. Gonzalo Cosa
University of Toronto Entrance Scholarship
R.F. Robertson Merit Award
Society for Chemical Industry Prize (2013)
Canadian Society for Chemsitry Silver Medal
John M. Walkley Jr. Memorial Award (2012-2013)
NSERC Undergraduate Student Research Award (2012)
Reactive Intermediate Student Exchange Scholarship (2011)
Alfred David G. Arthurs Scholarship (2010-2011)
Frederic J. Lemaistre Award (2010-2011)
Dr. Robert M. Brown Scholarship (2010-2011)
McGill University J.W. McConnel Entrance Scholarship (2009)
Godin, R.; Liu, H.-W.; Smith, L. J.; Krumova, K.; Cosa, G. "Intrinsic photophysical processes of bodipy cores uncovered at the single molecule level". 36th Meeting of the American Society for Photobiology (ASP), Delta Centre-Ville, Montréal, QC, June 24th, 2012.
Smith, L.; Leigh, W. J. "Stopped-flow kinetic studies of the reactivity of multiply bonded silicon and germanium compounds". Sixteenth International Symposium on Silicon Chemistry, McMaster University, Hamilton, ON. August 16th, 2011.
Smith, L.; Leigh, W. J. "Stopped-flow kinetic studies of the reactivity of multiply bonded silicon and germanium compounds". Reactive Intermediate Student Exchange Conference, University of Regina, Regina, SK. August 28th, 2011.
Publications & Book Chapters
Godin, R.; Liu, H.-W.; Smith, L.; Cosa, G. "Dye Lipophilicity and Retention in Lipid Membranes: Implications for Single Molecule Spectroscopy". Langmuir 2014, 30, 11138–11146.
PhD Candidate, 2014-present