Project

Lymphangioleiomyomatosis (LAM) is a rare lung disease characterized by the destruction of lung tissue by LAM cells. These cells are difficult to isolate and culture by traditional 2D cell culture methods, which presents a major obstacle in the study of LAM. My project deals with the development of a faithful cell culture model for LAM using biomimetic hyaluronan based hydrogels as a medium for 3D cell culture.

Education

McGill University
BSc Honours Bio-organic Chemistry, Minor in Interdisciplinary Life Sciences
First Class Honours, Distinction
Thesis Supervisor: Dr. Gonzalo Cosa

Awards
University of Toronto Entrance Scholarship
R.F. Robertson Merit Award
Society for Chemical Industry Prize (2013)
Canadian Society for Chemsitry Silver Medal
John M. Walkley Jr. Memorial Award (2012-2013)
NSERC Undergraduate Student Research Award (2012)
Reactive Intermediate Student Exchange Scholarship (2011)
Alfred David G. Arthurs Scholarship (2010-2011)
Frederic J. Lemaistre Award (2010-2011)
Dr. Robert M. Brown Scholarship (2010-2011)
McGill University J.W. McConnel Entrance Scholarship (2009)

Conferences

Godin, R.; Liu, H.-W.; Smith, L. J.; Krumova, K.; Cosa, G. "Intrinsic photophysical processes of bodipy cores uncovered at the single molecule level". 36th Meeting of the American Society for Photobiology (ASP), Delta Centre-Ville, Montréal, QC, June 24th, 2012.

Smith, L.; Leigh, W. J. "Stopped-flow kinetic studies of the reactivity of multiply bonded silicon and germanium compounds". Sixteenth International Symposium on Silicon Chemistry, McMaster University, Hamilton, ON. August 16th, 2011.

Smith, L.; Leigh, W. J. "Stopped-flow kinetic studies of the reactivity of multiply bonded silicon and germanium compounds". Reactive Intermediate Student Exchange Conference, University of Regina, Regina, SK. August 28th, 2011.

Publications & Book Chapters

Godin, R.; Liu, H.-W.; Smith, L.; Cosa, G. "Dye Lipophilicity and Retention in Lipid Membranes: Implications for Single Molecule Spectroscopy". Langmuir 2014, 30, 11138–11146.

PhD Candidate, 2014-present