Papers: 2000 – 2009


139. Leipzig ND; Shoichet MS. 2009 “The effect of substrate stiffness on adult neural stem cell behavior” Biomaterials, 30: 6867-78; doi: 10.1016/j.biomaterials.2009.09.002

138. Zahir T; Chen Y; Leipzig N; MacDonald J; Tator CH; Shoichet MS. 2009 “Neural stem/progenitor cells differentiate in vitro to neurons by the combined action of dibutyryl cAMP and interferon-γ” Stem Cells and Development, 18: 1423-32; doi: 10.1089/scd.2008.0412

137. Wang Y; Lapitsky Y; Kang CE; Shoichet MS. 2009 “Accelerated release of a sparingly soluble drug from an injectable hyaluronan-methylcellulose hydrogel” J Control Release, 140: 128-33; doi: 10.1016/j.jconrel.2009.05.025

136. Shi M; Lu J; Shoichet MS. 2009 "Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer" J Materials Chem, 19: 5485-98

135. Baumann MD; Kang CE; Stanwick JC; Wang Y; Kim H; Lapitsky Y; Shoichet MS. 2009 “An injectable drug delivery platform for sustained combination therapy” J Control Release, 138: 205-13; doi: 10.1016/j.jconrel.2009.05.009

134. Shi M; Ho K; Keating A; Shoichet MS. 2009 “Doxorubicin-conjugated immuno-nanoparticles for intracellular anticancer drug delivery” Advanced Functional Materials, 19: 1689-96; doi: 10.1021/bc8003167

133. Kang CE; Poon PC; Tator CH; Shoichet MS. 2009 “A new paradigm for local and sustained release of therapeutic molecules to the injured spinal cord for neuroprotection and tissue repair” Tissue Eng, 15: 595-604; doi: 10.1089/ten.tea.2007.0349

132. Ho K; Lapitsky Y; Shi M; Shoichet MS. 2009 “Tunable immunonanoparticle binding to cancer cells: thermodynamic analysis of targeted drug delivery vehicles” Soft Matter, 5: 1074-80; doi: 10.1039/B814204A

131. Lu J; Shi M; Shoichet MS. 2009 “Click chemistry functionalized polymeric nanoparticles target corneal epithelial cells through RGD-cell surface receptors” Bioconjugate Chemistry, 20: 87-94; doi: 10.1021/bc8003167

130. Baumann MD; Austin JW; Fehlings MG; Shoichet MS. 2009 ”A quantitative ELISA for bioactive anti-nogo-A, a promising regenerative molecule for spinal cord injury repair” Methods, 44: 104-08; doi: 10.1016/j.ymeth.2008.07.007


129. Aizawa Y; Leipzig N; Zahir T; Shoichet MS. 2008 “The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels” Biomaterials, 29: 4676-83; doi: 10.1016/j.biomaterials.2008.08.018

128. Nomura H; Zahir T; Baradie B; Kim H; Katayama Y; Kalbatski I; Morshead CM; Shoichet MS; Tator CH. 2008 “Extramedullary chitosan channels promote survival of transplanted neural stem and progenitor cells and create a tissue bridge after complete spinal cord transection” Tissue Eng, 14: 649-65; doi: 10.1089/tea.2007.0180

127. Shi M; Shoichet MS. 2008 “Furan-functionalized copolymers for targeted drug delivery: characterization, self-assembly and drug encapsulation” J Biomat Sci Polym Ed, 19: 1143-57; doi: 10.1163/156856208785540127

126. Nomura H; Baradie B; Katayama Y; Morshead CM; Shoichet MS; Tator CH. 2008 “Delayed implantation of intramedullary chitosan channels containing nerve grafts promotes extensive axonal regeneration after spinal cord injury”, Neurosurgery, 63: 127-4; doi: 10.1227/01.NEU.0000335080.47352.31

125. Nisbet DR; Yu LMY; Zahir T; Forsythe JS; Shoichet MS. 2008 “Characterization of neural stem cells on electrospun poly(ɛ-caprolactone) submicron scaffolds: evaluating their potential in neural tissue engineering” J Biomater Sci Polym Ed, 19: 623-34; doi: 10.1163/156856208784089652

124. Yu LMY; Wosnick JH; Shoichet MS. 2008 “Miniaturized system of neurotrophin patterning for guided regeneration” J Neurosci Methods, 171: 253-63; doi: 10.1016/j.jneumeth.2008.03.023

123. Yu LMY; Leipzig ND; Shoichet MS. 2008 "Promoting neuron adhesion and growth" Materials Today, 11: 36-43

122. Kim H; Tator CH; Shoichet MS. 2008 “Design of protein-releasing chitosan channels” Biotechnol Prog, 24: 932-37; doi: 10.1021/bp070352a

121. Zahir T; Nomura H; Guo XD; Kim H; Tator CH; Morshead CM; Shoichet MS. 2008 “Bioengineering neural stem/progenitor cell-coated tubes for spinal cord injury repair” Cell Transplant, 17: 245-54

120. Wylie RG; Shoichet MS. 2008 “Two-photon micropatterning of amines within an agarose hydrogel” J Mater Chem, 18: 2716-21; doi: 10.1039/B718431J

119. Shen YHA; Shoichet MS; Radisic M. 2008 “Vascular endothelial growth factor Immobilized in coll- agen scaffold promotes penetration and proliferation of endothelial cells” Acta Biomaterialia, 4: 477-89; doi: 10.1016/j.actbio.2007.12.011

118. Lapitsky Y; Zahir T; Shoichet MS. 2008 “Modular biodegradable biomaterials from surfactant and polyelectrolyte mixtures” Biomacromolecules, 9: 166-74; ; doi: 10.1021/bm7009416

117. Wosnick JH; Shoichet MS. 2008 “Three-dimensional chemical patterning of transparent hydrogels”. Chemistry of Materials, 20: 55-60; doi: 10.1021/cm071158m

116. Reynolds LF; Bren MC; Wilson BC; Gibson GD; Shoichet MS; Murphy RJ. 2008 “Transplantation of porous tubes following spinal cord transection improves hindlimb function in the rat” Spinal Cord, 46: 58-64; doi: 10.1038/


115. Poon PC; Gupta D; Shoichet MS; Tator CH. 2007 “Clip compression model is useful for thoracic spinal cord injuries: histologic and functional correlates” Spine, 32: 2853-59; doi: 10.1097/BRS.0b013e31815b7e6b

114. Conrad MPC; Shoichet MS. 2007 “Synthesis and thermal stability of hybrid fluorosilicone polymers” Polymer, 48: 5233-40; doi: 10.1016/j.polymer.2007.07.014

113. Shi M; Wosnick JH; Ho K; Keating A; Shoichet MS. 2007 “Immuno-polymeric nanoparticles by Diels-Alder chemistry, Angewandte Chemie International Edition, 46: 6126-6131; doi: 10.1002/anie.200701032

112. Levesque SG; Shoichet MS. 2007 “Synthesis of enzyme-degradable, peptide-crosslinked dextran hydrogels” Bioconjugate Chemistry, 18: 874-885; doi: 10.1021/bc0602127

111. Yu LMY; Kazazian K; Shoichet MS. 2007 “Peptide surface modification of methacrylamide chitosan for neural tissue engineering applications” J Biomed Mater Res A, 82: 243-55; doi: 10.1002/jbm.a.31069


110. Musoke-Zawedde P and Shoichet MS. 2006. “Anisotropic three-dimensional peptide channels guide neurite outgrowth within a biodegradable hydrogel matrix” Biomed Mater, 1:162-69; doi: 10.1088/1748-6041/1/3/011

109. Levesque SG; Shoichet MS. 2006 “Synthesis of cell-adhesive dextran hydrogels and macroporous scaffolds” Biomaterials, 27: 5277-85; doi: 10.1016/j.biomaterials.2006.06.004

108. Nomura, H.; Katayama, Y.; Shoichet, M.S.; Tator, C.H. 2006 “Complete spinal cord transection treated by implantation of a reinforced synthetic hydrogel channel results in syringomyelia and caudal migration of the rostral stump” J Neurosurgery, 59: 183-92; doi: 10.1227/01.NEU.0000219859.35349.EF

107. Nomura H; Tator CH; Shoichet MS. 2006 "Bioengineered strategies for spinal cord repair" J Neurotrauma, 23: 496-507; doi: 10.1089/neu.2006.23.496

106. Gupta D; Tator CH; Shoichet MS. 2006 “Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized drug delivery to the injured spinal cord” Biomaterials, 27: 2370-79; doi: 10.1016/j.biomaterials.2005.11.015

105. Goraltchouk A; Scanga V; Morshead CM; Shoichet MS. 2006. “Incorporation of protein-eluting microspheres into biodegradable nerve guidance channels for controlled release” J Controlled Release, 110: 400-07; doi: 10.1016/j.jconrel.2005.10.019

104. Tsai EC; Dalton PD; Shoichet MS; Tator CH. 2006 “Matrix inclusion within synthetic hydrogel channels improves specific supraspinal and local axonal regeneration after complete spinal cord transection” Biomaterials, 27: 519-33; doi: 10.1016/j.biomaterials.2005.07.025

103. Katayama Y; Montenegro R; Freier T; Midha R; Belkas JS; Shoichet MS. 2006 “Coil-reinforced hydrogel tubes promote nerve regeneration equivalent to that of nerve autografts” Biomaterials, 27: 505-18; doi: 10.1016/j.biomaterials.2005.07.016

102. Piotrowicz A; Shoichet MS. 2006 “Nerve guidance channels as drug delivery vehicles” Biomaterials, 27: 2018-27; doi: 10.1016/j.biomaterials.2005.09.042

101. Moore K; MacSween M; Shoichet MS. 2006 “Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds” Tissue Eng, 12: 267-78; doi: 10.1089/ten.2006.12.267


100. Goraltchouk A; Freier T; Shoichet MS. 2005 “Synthesis of degradable poly(l-lactide-co-ethylene glycol) porous tubes by liquid-liquid centrifugal casting for use as nerve guidance channels” Biomaterials, 26: 7555-63; doi: 10.1016/j.biomaterials.2005.05.026

99. Baradie B and Shoichet MS. 2005 “Novel fluoro-terpolymers for coatings applications” Macromolecules, 38: 5560-68; doi: 10.1021/ma047792s

98. Baradie B; Lai PHM; Shoichet MS. 2005 “Synthesis and characterization of novel polysiloxane-grafted fluoropolymers” Can J Chem, 83: 553-58; doi: 10.1139/v05-068

97. Freier T; Koh HS; Kazazian K; Shoichet MS. 2005 “Controlling cell adhesion and degradation of chitosan films by N-acetylation” Biomaterials, 26: 5872-78; doi: 10.1016/j.biomaterials.2005.02.033

96. Levesque SG; Lim RM; Shoichet MS. 2005 “Macroporous interconnected dextran scaffolds of controlled porosity for tissue-engineering applications” Biomaterials, 26: 7436-46; doi: 10.1016/j.biomaterials.2005.05.054

95. Karp J; Tanaka TS; Zohar R; Sodek J; Shoichet MS; Davies JE; Stanford WL. 2005 “Thrombin mediated migration of osteogenic cells” Bone, 37: 337-48; doi: 10.1016/j.bone.2005.04.022

94. Jimenez Hamann MC; Tator CH; Shoichet MS. 2005 “Injectable intrathecal delivery system for localized administration of EGF and FGF-2 to the injured rat spinal cord” Experimental Neurology, 194: 106-19; doi: 10.1016/j.expneurol.2005.01.030

93. Freier T; Montenegro R; Koh HS; Shoichet MS. 2005 “Chitin-based tubes for tissue engineering in the nervous system” Biomaterials, 26: 4624-32; doi: 10.1016/j.biomaterials.2004.11.040

92. Belkas JS; Munro CA; Shoichet MS; Midha R. 2005 “Peripheral nerve regeneration through a synthetic hydrogel nerve tube,” J Restorative Neurology & Neuroscience, 23: 19-29

91. Belkas JS; Munro CA; Shoichet MS; Johnston M; Midha R. 2005 “Long-term in vivo biomechanical properties and biocompatibility of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) nerve conduits” Biomaterials, 26: 1741-49; doi: 10.1016/j.biomaterials.2004.05.031

90. Yu TT; Shoichet MS. 2005 “Guided cell adhesion and outgrowth in peptide-modified channels for tissue engineering”, Biomaterials, 26: 1507-14; doi: 10.1016/j.biomaterials.2004.05.012


89. Luo Y; Shoichet MS. 2004 “Light-activated Immobilization of biomolecules to agarose hydrogels for conrolled cellular response”, Biomacromolecules, 5: 2315-23; doi: 10.1021/bm0495811

88. Karp JM; Sarraf F; Shoichet MS; Davies JE. 2004 “Fibrin-filled scaffolds for bone-tissue engineering: an in vivo study,” J Biomed Mater Res A: 71:162-71; doi: 10.1002/jbm.a.30147

87. Baradie B; Shoichet MS; Shen Z; McHugh M; Hong L; Wang Y; Johnson JK; Beckman E; Enick R. 2004 “Synthesis and solubility of linear poly(tetrafluoroethylene-co-vinyl acetate) in dense CO2: Experimental and molecular modeling results” Macromolecules, 37: 7799-807; doi: 10.1021/ma049384u

86. Belkas JS; Shoichet MS; Midha R. 2004 “Peripheral nerve regeneration through guidance tubes” Neurological Research, 26: 151-60; doi: 10.1179/016164104225013798

85. Luo Y; Shoichet MS. 2004 “A photolabile hydrogel for guided 3-D cell growth and migration”, Nature Materials, 3: 249-53; doi: 10.1038/nmat1092

84. Tsai EC; Dalton PD; Shoichet MS; Tator CH. 2004 “Synthetic hydrogel guidance channels facilitate regeneration of adult rat brainstem motor axons after complete spinal cord transection” J. Neurotrauma, 21: 789-804; doi: 10.1089/0897715041269687

83. Enescu C; Shoichet MS. 2004 “Controlling modulus and morphology of hydrogel tubes through surface modification” J Biomater Sci Polym Ed, 15: 215-27; doi: 10.1163/156856204322793593

82. Kapur TA; Shoichet MS. 2004 “Immobilized concentration gradients of nerve growth factor guide neurite outgrowth”, J Biomed Mater Res A, 68:235-43; doi: 10.1002/jbm.a.10168

81. Belkas J; Midha R; Shoichet MS. 2004 “Axonal guidance channels in peripheral nerve regeneration” Operative Techniques in Orthopaedics, 14: 190-98


80. Cao X; Shoichet MS. 2003 “Investigating the synergistic effect of combined neurotrophic factor concentration gradients to guide axonal growth” Neuroscience, 122: 381-89; doi: 10.1016/j.neuroscience.2003.08.018

79. Fialkov JA; Holy CE; Shoichet MS; Davies JE. 2003 “In vivo bone engineering in a rabbit femur” J Craniofacial Surgery, 14: 324-32

78. Karp JM; Rzeszutek K; Shoichet MS; Davies JE. 2003 “Fabrication of precise cylindrical 3-D tissue engineering scaffolds for in vitro and in vivo bone engineering applications” J Craniofacial Surgery, 14: 317-23

77. Shaw D; Shoichet MS. 2003 “Towards spinal cord injury repair strategies: peptide surface modification of expanded poly(tetrafluoroethylene) fibers for guided neurite outgrowth in vitro” J Craniofacial Surgery, 14: 308-16

76. Baradie B; Shoichet MS. 2003 “Insight into the surface properties of fluorocarbon-vinyl acetate copolymer films and blends” Macromolecules, 36: 2343-48; doi: 10.1021/ma0216019

75. Flynn L; Dalton PD; Shoichet MS. 2003 “Fiber templating of poly(2-hydroxyethyl methacrylate) for neural tissue engineering” Biomaterials, 24: 4265-72; doi: 10.1016/S0142-9612(03)00334-X

74. Midha R; Munro CA; Dalton PD; Tator CH; Shoichet MS. 2003 “Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube” J. Neurosurg., 99:555-65; doi: 10.3171/jns.2003.99.3.0555

73. Jimenez Hamann MC; Tsai EC; Tator CH; Shoichet MS. 2003 “Novel intrathecal delivery system for treatment of spinal cord injury” Experimental Neurology, 182: 300-309; doi: 10.1016/S0014-4886(03)00040-2

72. Kapur TA; Shoichet MS. 2003 “Chemically-bound nerve growth factor for neural tissue engineering applications”, J Biomater Sci Polym Ed, 14: 383-94

71. Holy CE; Fialkov J; Davies JE; Shoichet MS. 2003 “Use of a biomimetic strategy to engineer bone” J Biomed Mater Res A, 65: 447-53; doi: 10.1002/jbm.a.10453

70. Karp JM; Shoichet MS; Davies JE. 2003 “Bone formation on 2-D PLGA films and 3-D tissue engineering scaffolds in vitro” J Biomater Sci Polym Ed, 64:388-96; doi: 10.1002/jbm.a.10420

69. Karp JM; Dalton PD; Shoichet MS. 2003 “Scaffolds for tissue engineering” MRS Bulletin on Cellular Solids, 28: 301-06 (Invited Review)


68. Dalton PD; Flynn L; Shoichet MS. 2002 “Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels” Biomaterials, 23: 3843-51; doi: 10.1016/S0142-9612(02)00120-5

67. Cao X; Shoichet MS. 2002 “Photoimmobilization of biomolecules within a 3-dimensional hydrogel matrix” J Biomater Sci Polym Ed, 13: 623-36; doi: 10.1163/156856202320269120

66. Baradie B; Shoichet MS. 2002 “Synthesis of fluorocarbon-vinyl acetate copolymers in supercritical carbon dioxide: Insight into bulk properties” Macromolecules, 35: 3569-75; doi: 10.1021/ma010461k


65. Luo Y; Dalton PD; Shoichet MS. 2001 “Investigating the properties of novel poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel hollow fiber membranes” Chem of Mater, 13: 4087-93; doi: 10.1021/cm010323

64. Cao X; Shoichet MS. 2001 “Defining the concentration gradient of nerve growth factor for guided neurite outgrowth” Neuroscience, 103: 831-40; doi: 10.1016/S0306-4522(01)00029-X

63. Dalton PD; Shoichet MS. 2001 “Creating porous tubes by centrifugal forces for soft tissue application” Biomaterials, 22: 2661-69; doi: 10.1016/S0142-9612(01)00008-4

62. Tong YW; Shoichet MS. 2001 “Enhancing the neuronal interaction on fluoropolymer surfaces with mixed peptides or spacer group linkers” Biomaterials, 22: 1029-34; doi: 10.1016/S0142-9612(00)00338-0

61. Holy CE; Cheng C; Davies JE; Shoichet MS. 2001 “Optimizing the sterilization of PLGA scaffolds for use in tissue engineering” Biomaterials, 22: 25-31; doi: 10.1016/S0142-9612(00)00136-8


60. Yuan Y; Shoichet MS. 2000 “Surface enrichment of poly(trifluorovinyl ether)s in polystyrene blends” Macromolecules, 33: 4926-31; doi: 10.1021/ma000147a

59. Holy CE; Shoichet MS; Davies JE. 2000 “Engineering 3-D bone tissue in vitro using biodegradable scaffolds: Investigating initial cell-seeding density and culture period” J Biomed Mater Res, 51:376-82; doi: 10.1002/1097-4636(20000905)51:3<376::AID-JBM11>3.0.CO;2-G

58. Lousenberg RD; Shoichet MS. 2000 “Radical copolymerization of novel trifluorovinyl ethers with ethyl vinyl ether and vinyl acetate: Estimating reactivity ratios and understanding reactivity behavior of the propagating radical” J Polym Sci A Polym Chem, 38: 1344-54; doi: 10.1002/(SICI)1099-0518(20000415)38:8<1344::AID-POLA19>3.0.CO;2-D

57. Saneinejad S; Shoichet MS. 2000 “Patterned poly(chlorotrifluoroethylene) guides primary nerve cell adhesion and neurite outgrowth” J Biomed Mater Res, 50: 465-74; doi: 0.1002/(SICI)1097-4636(20000615)50:43.0.CO;2-K

56. Lousenberg RD; Shoichet MS. 2000 “Synthesis of linear poly(tetrafluoroethylene-co-vinyl acetate) in carbon dioxide” Macromolecules, 33: 1682-85; doi: 10.1021/ma991256w

55. Shoichet MS and Winn SR.  2000 “Cell delivery to the central nervous system” Advanced Drug Delivery Reviews Vol. 42 (1-2):  81-102 (Invited Review)