Papers: 2000 – 2009


129. Leipzig, N.D.; Shoichet, M.S. 2009 “The effect of substrate stiffness on adult neural stem cell behavior” Biomaterials, 30: 6867-78

128. Zahir, T.; Chen, Y.; Leipzig, N.; MacDonald, J.; Tator, C.H.; Shoichet, M.S. 2009 “Neural stem/progenitor cells differentiate in vitro to neurons by the combined action of dibutyryl cAMP and interferon-γ” Stem Cells and Development, 18: 1423-32

127. Wang, Y.; Lapitsky, Y.; Kang, C.E.; Shoichet, M.S. 2009 “Accelerated release of a sparingly soluble drug from an injectable hyaluronan-methylcellulose hydrogel” J Control Release, 140: 128-33

126. Shi M; Lu J; Shoichet MS. 2009 "Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer" J Materials Chem, 19: 5485-98

125. Baumann, M.D.; Kang, C.E.; Stanwick, J.C.; Wang, Y.; Kim, H.; Lapitsky, Y.; Shoichet, M.S. 2009 “An injectable drug delivery platform for sustained combination therapy” J Control Release, 138: 205-13

124. Shi, M.; Ho, K.; Keating, A.; Shoichet, M.S. 2009 “Doxorubicin-conjugated immuno-nanoparticles for intracellular anticancer drug delivery” Advanced Functional Materials, 19: 1689-96

123. Kang, C.E.; Poon, P.C.; Tator, C.H.; Shoichet, M.S. 2009 “A new paradigm for local and sustained release of therapeutic molecules to the injured spinal cord for neuroprotection and tissue repair” Tissue Eng, 15: 595-604

122. Ho, K.; Lapitsky, Y.; Shi, M.; Shoichet, M.S. 2009 “Tunable immunonanoparticle binding to cancer cells: thermodynamic analysis of targeted drug delivery vehicles” Soft Matter, 5: 1074-80

121. Lu, J.; Shi, M.; Shoichet, M.S. 2009 “Click chemistry functionalized polymeric nanoparticles target corneal epithelial cells through RGD-cell surface receptors” Bioconjugate Chemistry, 20: 87-94

120. Baumann, M.D.; Austin, J.W.; Fehlings, M.G.; Shoichet, M.S. 2009 ”A quantitative ELISA for bioactive anti-nogo-A, a promising regenerative molecule for spinal cord injury repair” Methods, 44: 104-08


119. Aizawa, Y.; Leipzig, N.; Zahir, T.; Shoichet, M.S. 2008 “The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels” Biomaterials, 29: 4676-83

118. Nomura, H.; Zahir, T.; Baradie, B.; Kim, H.; Katayama, Y.; Kalbatski, I.; Morshead, C.M.; Shoichet, M.S.; Tator, C.H. 2008 “Extramedullary chitosan channels promote survival of transplanted neural stem and progenitor cells and create a tissue bridge after complete spinal cord transection” Tissue Eng, 14: 649-665

117. Shi, M.; Shoichet, M.S. 2008 “Furan-functionalized copolymers for targeted drug delivery: characterization, self-assembly and drug encapsulation” J Biomat Sci Polym Ed, 19: 1143-57

116. Nomura, H.; Baradie, B.; Katayama, Y.; Morshead, C.M.; Shoichet, M.S.; Tator, C.H. 2008 “Delayed implantation of intramedullary chitosan channels containing nerve grafts promotes extensive axonal regeneration after spinal cord injury”, Neurosurgery, 63: 127-43

115. Nisbet, D.R.; Yu, L.M.Y.; Zahir, T.; Forsythe, J.S.; Shoichet, M.S. 2008 “Characterization of neural stem cells on electrospun poly(-caprolactone) submicron scaffolds: evaluating their potential in neural tissue engineering” J Biomater Sci Polym Ed, 19: 623-34

114. Yu, L.M.Y.; Wosnick, J.H.; Shoichet, M.S. 2008 “Miniaturized system of neurotrophin patterning for guided regeneration” J Neurosci Methods, 171: 253-63

113. Yu LMY; Leipzig ND; Shoichet MS. 2008 "Promoting neuron adhesion and growth" Materials Today, 11: 36-43

112. Kim, H.; Tator, C.H.; Shoichet, M.S. 2008 “Design of protein-releasing chitosan channels” Biotechnol Prog, 24: 932-37

111. Zahir, T.; Nomura, H.; Guo, X.D.; Kim, H.; Tator, C.H.; Morshead, C.M.; Shoichet, M.S. 2008 “Bioengineering neural stem/progenitor cell-coated tubes for spinal cord injury repair” Cell Transplant, 17: 245-54

110. Wylie, R.G.; Shoichet, M.S. 2008 “Two-photon micropatterning of amines within an agarose hydrogel” J Mater Chem, 18: 2716-21

109. Shen, Y.H.A.; Shoichet, M.S.; Radisic, M. 2008 “Vascular endothelial growth factor Immobilized in coll- agen scaffold promotes penetration and proliferation of endothelial cells” Acta Biomaterialia, 4: 477-89

108. Lapitsky, Y.; Zahir, T.; Shoichet, M.S. 2008 “Modular biodegradable biomaterials from surfactant and polyelectrolyte mixtures” Biomacromolecules, 9: 166-74

107. Wosnick, J.H.; Shoichet, M.S. 2008 “Three-dimensional chemical patterning of transparent hydrogels”. Chemistry of Materials, 20: 55-60

106. Reynolds, L.F.; Bren, M.C.; Wilson, B.C.; Gibson, G.D.; Shoichet, M.S.; Murphy, R.J. 2008 “Transplantation of porous tubes following spinal cord transection improves hindlimb function in the rat” Spinal Cord, 46: 58-64


105. Poon, P.C.; Gupta, D.; Shoichet, M.S.; Tator, C.H. 2007 “Clip compression model is useful for thoracic spinal cord injuries: histologic and functional correlates” Spine, 32: 2853-59

104. Conrad, M.P.C.; Shoichet, M.S. 2007 “Synthesis and thermal stability of hybrid fluorosilicone polymers” Polymer, 48: 5233-40

103. Shi, M.; Wosnick, J.H.; Ho, K.; Keating, A.; Shoichet, M.S. 2007 “Immuno-polymeric nanoparticles by Diels-Alder chemistry, Angewandte Chemie International Edition, 46: 6126-6131

102. Levesque, S.G.; Shoichet, M.S. 2007 “Synthesis of enzyme-degradable, peptide-crosslinked dextran hydrogels” Bioconjugate Chemistry, 18: 874-885

101. Yu L.M.Y.; Kazazian, K.; Shoichet MS. 2007 “Peptide surface modification of methacrylamide chitosan for neural tissue engineering applications” J Biomed Mater Res A, 82: 243-55


100. Musoke-Zawedde, P. and Shoichet MS. 2006. “Anisotropic three-dimensional peptide channels guide neurite outgrowth within a biodegradable hydrogel matrix” Biomed Mater, 1:162-69

99. Levesque, S.G.; Shoichet, MS. 2006 “Synthesis of cell-adhesive dextran hydrogels and macroporous scaffolds” Biomaterials, 27: 5277-85

98. Nomura, H.; Katayama, Y.; Shoichet, M.S.; Tator, C.H. 2006 “Complete spinal cord transection treated by implantation of a reinforced synthetic hydrogel channel results in syringomyelia and caudal migration of the rostral stump” J Neurosurgery, 59: 183-92

97. Nomura H; Tator CH; Shoichet MS. 2006 "Bioengineered strategies for spinal cord repair" J Neurotrauma, 23: 496-507

96. Gupta D; Tator CH; Shoichet MS. 2006 “Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized drug delivery to the injured spinal cord” Biomaterials, 27: 2370-2379

95. Goraltchouk, A.; Scanga, V.; Morshead, C.M.; Shoichet, MS. 2006. “Incorporation of protein-eluting microspheres into biodegradable nerve guidance channels for controlled release” J Controlled Release, 110: 400-407

94. Tsai, E.C.; Dalton, P.D.; Shoichet, M.S.; Tator, C.H. 2006 “Matrix inclusion within synthetic hydrogel channels improves specific supraspinal and local axonal regeneration after complete spinal cord transection” Biomaterials, 27: 519-33

93. Katayama, Y.; Montenegro, R.; Freier, T.; Midha, R.; Belkas, J.S.; Shoichet, M.S. 2006 “Coil-reinforced hydrogel tubes promote nerve regeneration equivalent to that of nerve autografts” Biomaterials, 27: 505-18

92. Piotrowicz, A.; Shoichet, M.S. 2006 “Nerve guidance channels as drug delivery vehicles” Biomaterials, 27: 2018-27

91. Moore, K.; MacSween, M. and Shoichet, M.S. 2006 “Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds” Tissue Eng, 12: 267-78


90. Goraltchouk, A.; Freier, T.; Shoichet, M.S. 2005 “Synthesis of degradable poly(l-lactide-co-ethylene glycol) porous tubes by liquid-liquid centrifugal casting for use as nerve guidance channels” Biomaterials, 26: 7555-63

89. Baradie, B. and Shoichet M.S. 2005 “Novel fluoro-terpolymers for coatings applications” Macromolecules, 38: 5560-68

88. Baradie, B.; Lai, P.H.M.; Shoichet, M.S. 2005 “Synthesis and characterization of novel polysiloxane-grafted fluoropolymers” Can J Chem, 83: 553-58

87. Freier, T.; Koh, H.S.; Kazazian, K.; Shoichet, M.S. 2005 “Controlling cell adhesion and degradation of chitosan films by N-acetylation” Biomaterials, 26: 5872-78

86. Levesque, S.G.; Lim, R.M.; Shoichet, M.S. 2005 “Macroporous interconnected dextran scaffolds of controlled porosity for tissue-engineering applications” Biomaterials, 26: 7436-46

85. Karp, J.; Tanaka, T.S.; Zohar, R.; Sodek, J.; Shoichet, M.S.; Davies, J.E.; Stanford, W.L. 2005 “Thrombin mediated migration of osteogenic cells” Bone, 37: 337-48

84. Jimenez Hamann, M.C.; Tator, C.H.; Shoichet, M.S. 2005 “Injectable intrathecal delivery system for localized administration of EGF and FGF-2 to the injured rat spinal cord” Experimental Neurology, 194: 106-19

83. Freier, T.; Montenegro, R.; Koh, H.S.; Shoichet, M.S. 2005 “Chitin-based tubes for tissue engineering in the nervous system” Biomaterials, 26: 4624-32

82. Belkas, J.S.; Munro, C.A.; Shoichet, M.S.; Midha, R. 2005 “Peripheral nerve regeneration through a synthetic hydrogel nerve tube,” J Restorative Neurology & Neuroscience, 23: 19-29

81. Belkas, J.S; Munro, C.A.; Shoichet, M.S.; Johnston, M.; Midha, R. 2005 “Long-term in vivo biomechanical properties and biocompatibility of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) nerve conduits” Biomaterials, 26: 1741-49

80. Yu T.T.; Shoichet, M.S. 2005 “Guided cell adhesion and outgrowth in peptide-modified channels for tissue engineering”, Biomaterials, 26: 1507-14


79. Luo, Y.; Shoichet, M.S. 2004 “Light-activated Immobilization of biomolecules to agarose hydrogels for conrolled cellular response”, Biomacromolecules, 5: 2315-23

78. Karp, J.M.; Sarraf, F., Shoichet, M.S.; Davies, J.E. 2004 “Fibrin-filled scaffolds for bone-tissue engineering: An in vivo study,” J Biomed Mater Res A: 71:162-71

77. Baradie, B.; Shoichet, M.S.; Shen, Z.; McHugh, M.; Hong, L.; Wang, Y.; Johnson, J.K., Beckman, E.; Enick, R. 2004 “Synthesis and solubility of linear poly(tetrafluoroethylene-co-vinyl acetate) in dense CO2: Experimental and molecular modeling results” Macromolecules, 37: 7799-807

76. Belkas, J.S.; Shoichet, M.S.; Midha, R. 2004 “Peripheral nerve regeneration through guidance tubes” Neurological Research, 26: 151-60

75. Luo, Y.; Shoichet, M.S. 2004 “A photolabile hydrogel for guided 3-D cell growth and migration”, Nature Materials, 3: 249-53

74. Tsai, E.C.; Dalton, P.D.; Shoichet, M.S.; Tator, C.H. 2004 “Synthetic hydrogel guidance channels facilitate regeneration of adult rat brainstem motor axons after complete spinal cord transection” J. Neurotrauma, 21: 789-804

73. Enescu, C.; Shoichet, M.S. 2004 “Controlling modulus and morphology of hydrogel tubes through surface modification” J Biomater Sci Polym Ed, 15: 215-27

72. Kapur, T.A.; Shoichet, M.S. 2004 “Immobilized concentration gradients of nerve growth factor guide neurite outgrowth”, J Biomed Mater Res A, 68:235-43


71. Cao, X.; Shoichet, M.S. 2003 “Investigating the synergistic effect of combined neurotrophic factor concentration gradients to guide axonal growth” Neuroscience, 122: 381-89

70. Fialkov, J.A.; Holy, C.E.; Shoichet, M.S.; Davies, J.E. 2003 “In vivo bone engineering in a rabbit femur” J Craniofacial Surgery, 14: 324-32

69. Karp, J.M.; Rzeszutek, K.; Shoichet, M.S.; Davies, J.E. 2003 “Fabrication of precise cylindrical 3-D tissue engineering scaffolds for in vitro and in vivo bone engineering applications” J Craniofacial Surgery, 14: 317-23

68. Shaw, D.; Shoichet, M.S. 2003 “Towards spinal cord injury repair strategies: peptide surface modification of expanded poly(tetrafluoroethylene) fibers for guided neurite outgrowth in vitro” J Craniofacial Surgery, 14: 308-16

67. Baradie, B.; Shoichet, M.S. 2003 “Insight into the surface properties of fluorocarbon-vinyl acetate copolymer films and blends” Macromolecules, 36: 2343-48

66. Flynn, L.; Dalton, P.D.; Shoichet, M.S. 2003 “Fiber templating of poly(2-hydroxyethyl methacrylate) for neural tissue engineering” Biomaterials, 24: 4265-72

65. Midha, R.; Munro, C.A.; Dalton, P.D.; Tator, C.H.; Shoichet, M.S. 2003 “Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube” J. Neurosurg., 99:555-65

64. Jimenez Hamann, M.C.; Tsai, E.C.; Tator, C.H.; Shoichet, M.S. 2003 “Novel intrathecal delivery system for treatment of spinal cord injury” Experimental Neurology, 182: 300-309

63. Kapur, T.A.; Shoichet, M.S. 2003 “Chemically-bound nerve growth factor for neural tissue engineering applications”, J Biomater Sci Polym Ed, 14: 383-94

62. Holy, C.E.; Fialkov, J.; Davies, J.E.; Shoichet, M.S. 2003 “Use of a biomimetic strategy to engineer bone” J Biomed Mater Res A, 65: 447-53

61. Karp, J.M.; Shoichet, M.S.; Davies, J.E. 2003 “Bone formation on 2-D PLGA films and 3-D tissue engineering scaffolds in vitro” J Biomater Sci Polym Ed, 64:388-96


60. Dalton, P.D.; Flynn, L.; Shoichet, M.S. 2002 “Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels” Biomaterials, 23: 3843-51

59. Cao, X.; Shoichet, M.S. 2002 “Photoimmobilization of biomolecules within a 3-dimensional hydrogel matrix” J Biomater Sci Polym Ed, 13: 623-36

58. Baradie, B.; Shoichet, M.S. 2002 “Synthesis of fluorocarbon-vinyl acetate copolymers in supercritical carbon dioxide: Insight into bulk properties” Macromolecules, 35: 3569-75


57. Luo, Y.; Dalton, P.D.; Shoichet, M.S. 2001 “Investigating the properties of novel poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel hollow fiber membranes” Chem of Mater, 13: 4087-93

56. Cao, X.; Shoichet, M.S. 2001 “Defining the concentration gradient of nerve growth factor for guided neurite outgrowth” Neuroscience, 103: 831-40

55. Dalton, P.D.; Shoichet, M.S. 2001 “Creating porous tubes by centrifugal forces for soft tissue application” Biomaterials, 22: 2661-69

54. Tong, Y.W.; Shoichet, M.S. 2001 “Enhancing the neuronal interaction on fluoropolymer surfaces with mixed peptides or spacer group linkers” Biomaterials, 22: 1029-34

53. Holy, C.E.; Cheng, C.; Davies, J.E.; Shoichet, M.S. 2001 “Optimizing the sterilization of PLGA scaffolds for use in tissue engineering” Biomaterials, 22: 25-31


52. Yuan, Y.; Shoichet, M.S. 2000 “Surface enrichment of poly(trifluorovinyl ether)s in polystyrene blends” Macromolecules, 33: 4926-31

51. Holy, C.E.; Shoichet, M.S.; Davies, J.E. 2000 “Engineering 3-D bone tissue in vitro using biodegradable scaffolds: Investigating initial cell-seeding density and culture period” J Biomed Mater Res, 51:376-82

50. Lousenberg, R.D.; Shoichet, M.S. 2000 “Radical copolymerization of novel trifluorovinyl ethers with ethyl vinyl ether and vinyl acetate: Estimating reactivity ratios and understanding reactivity behavior of the propagating radical” J Polym Sci A Polym Chem, 38: 1344-54

49. Saneinejad, S.; Shoichet, M.S. 2000 “Patterned poly(chlorotrifluoroethylene) guides primary nerve cell adhesion and neurite outgrowth” J Biomed Mater Res, 50: 465-74

48. Lousenberg, R.D.; Shoichet, M.S. 2000 “Synthesis of linear poly(tetrafluoroethylene-co-vinyl acetate) in carbon dioxide” Macromolecules, 33: 1682-85